NCT06834776

Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients

Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients Undergoing Elective Surgery Under General Anesthesia, Monitored by Train-of-Four (TOF)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 104 (estimated)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins. The study will assess the depth of neuromuscular blockade, recovery time, and postoperative residual curarization using Train-of-Four (TOF) monitoring, with the primary goal of determining whether statin use alters the neuromuscular blockade management.

Conditions

• Neuromuscular Blockade
• Statin-Associated Myopathy
• Neuromuscular Monitoring

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.	General anesthesia with propofol and fentanyl induction followed by rocuronium for neuromuscular blockade; maintenance with desflurane and remifentanil.

Timeline

• Start date: 2025-02-15
• Primary completion: 2025-11-15
• Completion: 2025-12-15
• First posted: 2025-02-19
• Last updated: 2025-02-19