NCT06834594

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome

Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome: A Non-randomized Prospective Trial (The BOOST Study)

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Children's Mercy Hospital Kansas City · Academic / Other
• Sex: Female
• Age: 12 Years – 20 Years
• Healthy volunteers: Not accepted

Summary

This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).

Conditions

• Turner Syndrome
• Primary Ovarian Insufficiency (Poi)

Interventions

Type	Name	Description
DRUG	Micronized progesterone 200 MG	Oral micronized progesterone 200mg for the first 12 days of a 30 to 31-day cycle
DRUG	Micronized Progesterone 100 MG	Oral micronized progesterone 100mg daily taken throughout the 30 to 31-day cycle.

Timeline

• Start date: 2025-07-31
• Primary completion: 2026-07-30
• Completion: 2026-07-31
• First posted: 2025-02-19
• Last updated: 2025-09-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study