NCT06831110

Aquagenic Wrinkling Prediction

Using Aquagenic Wrinkling to Predict CF Carrier State

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: University of Iowa · Academic / Other
• Sex: All
• Age: 18 Years – 24 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status. Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.

Conditions

• Aquagenic Wrinkling of Palms
• Carrier State

Interventions

Type	Name	Description
PROCEDURE	Aquagenic Wrinkling	Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.

Timeline

• Start date: 2025-03-06
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-02-17
• Last updated: 2025-05-31

Locations

1 site across 1 country: United States