NCT06831019

The ROAR Study: Reactive Oxygen Species and Reproduction

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,100 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 43 Years
• Healthy volunteers: Accepted

Summary

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Conditions

• Ovarian Aging
• IVF Outcome
• Oxidative Stress

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Oxidative stress markers	We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Timeline

• Start date: 2025-07-07
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2025-02-17
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States