NCT06830980

Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Gopalkumar Rakesh · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.

Detailed description

The investigators will compare how two theta burst paradigms, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), compare with sham TMS in changing methamphetamine craving and brain activity. iTBS, cTBS, and sham TMS will be delivered in an accelerated fashion (two sessions daily, separated by 50 minutes). iTBS will be delivered to the left dorsolateral prefrontal cortex (left dorsolateral prefrontal cortex), and cTBS will be delivered to the frontal pole. A brain MRI scan will be done before and after the iTBS/cTBS/sham TMS sessions. The study involves four visits. Each visit will last three hours. Hence, participants will spend a total of 12 hours in the study.

Conditions

• Methamphetamine Use Disorders
• HIV

Interventions

Type	Name	Description
DEVICE	intermittent theta burst stimulation (iTBS)	iTBS is an excitatory TMS paradigm that delivers 1800 pulses to the left dlPFC. Participants will receive 2 iTBS sessions separated by 50 minutes.
DEVICE	continuous theta burst stimulation (cTBS)	cTBS is an inhibitory TMS paradigm that delivers 1800 pulses to the frontal pole. Participants will receive 2 iTBS sessions separated by 50 minutes.
DEVICE	Sham TMS	Sham TMS delivered with the MagVenture B65 A/P coil

Timeline

• Start date: 2025-03-11
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-02-17
• Last updated: 2025-10-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study