NCT06829446

Recurrent Persistent Atrial Fibrillation:In-situ Ablation Vs Extensive Ablation

A Randomized Control Study of Repeat In-situ Ablation Versus Extensive Ablation for Patients with Recurrent Persistent Atrial Fibrillation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (actual)
• Sponsor: Shanghai Chest Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an open label, randomized parallel control clinical trial, to compare extra-PV extensive ablation with in-situ ablation as two strategies for the treatment of PerAF to identify the mechanisms of PerAF recurrence.

Detailed description

This is an open label, randomized parallel control clinical trial. Patients with recurrent persistent atrial fibrillation are 1:1 randomized into EXT group(Extra-PV extensive ablation) and IN-SITU group(Repeat same PVI and linear ablation as the first procedure). Postoperative recurrence rate and other indicators are analyzed to compare extra-PV extensive ablation with in-situ ablation as two strategies for the treatment of PerAF to identify the mechanisms of PerAF recurrence.

Conditions

• Recurrent Persistent Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	Extra-PV extensive ablation	Extra-PV extensive ablation
PROCEDURE	Repeat same PVI and linear ablation as the first procedure	Repeat same PVI and linear ablation as the first procedure

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-12-31
• Completion: 2023-12-31
• First posted: 2025-02-17
• Last updated: 2025-02-17

Locations

1 site across 1 country: China