NCT06828952

Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Ahmed Mohammed Hussein Sayed · Academic / Other
• Sex: All
• Age: 16 Years – 60 Years
• Healthy volunteers: Accepted

Summary

From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells/dL, CRP mg/L, appendix diameter mm, modified Alvarado score , and adult appendicitis score .

Detailed description

Expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . It is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Conditions

• Conservative Management

Interventions

Type	Name	Description
DRUG	ceftriaxone	ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
DRUG	ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly	Conservative management

Timeline

• Start date: 2025-06-22
• Primary completion: 2025-12-01
• Completion: 2025-12-02
• First posted: 2025-02-17
• Last updated: 2025-02-17

Locations

1 site across 1 country: Egypt