NCT06827678

Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 45 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population. We aimed to: * To reveal the progress of AD by multiple neuroimage and biomarkers; * To reveal the longitudinal change of biomarkers and cognition of AD in Chinese population; * To investigate the interaction of markers between body and brain; * To set up new markers by neuroimage.

Detailed description

The observational study is recruiting participants from clinics and communities with cognitive impairments and un-impairments. As the part of our previous study: Chinese Preclinical Alzheimer's Disease Study (C-PAS) cohort. We will include lager size of body and brain PET imaging. The study will also integrate multi-dimensional scales, peripheral biomarkers, metabolites, electroencephalograms, genetics, and other indicators for multi-omics analysis to deeply explore the mechanisms underlying the onset and progression of Alzheimer's disease. By identifying risk factors closely associated with Alzheimer's disease, we aim to develop a comprehensive disease risk model, providing reliable evidence for early detection and prevention, and uncovering new targets for therapeutic interventions.

Conditions

• Alzheimer Disease
• Positron Emission Tomography

Interventions

Type	Name	Description
OTHER	No Intervention: Observational Cohort	No intervention

Timeline

• Start date: 2022-08-01
• Primary completion: 2027-07-30
• Completion: 2027-07-30
• First posted: 2025-02-14
• Last updated: 2025-06-05

Locations

1 site across 1 country: China