NCT06827197

Role of Interleukin-1β and Prostaglandin E2 in Prediction and Outcome of Apnea in Neonates

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 1 Day – 2 Months
• Healthy volunteers: Not accepted

Summary

Our thesis proposed that IL-1β may affect brainstem respiratory control via prostaglandin-dependant mechanism so we investigated the mediator roles of IL-1β and PGE2 levels in predicting apnea in pretertm newborn and their relation to clinical outcomes.

Conditions

• Premature Newborns
• Premature Newborns With Gestational Age 28 to 33 Weeks

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood test	Blood samples were withdrawn from all the neonates under strict aseptic conditions and stored at -80°C for detecting PGE2 and IL-1β levels. PGE2 and IL-1β concentrations were measured using ELISA.

Timeline

• Start date: 2023-05-01
• Primary completion: 2023-10-01
• Completion: 2023-10-30
• First posted: 2025-02-14
• Last updated: 2025-02-14

Locations

2 sites across 1 country: Egypt