NCT06825962

The Effect of Hydration on Postprandial Metabolic Responses

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (estimated)
• Sponsor: Loughborough University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Certain populations, such as industrial workers and endurance athletes are particularly susceptible to dehydration due to exposure to heat for long periods of time causing evaporative water loss via sweating. The physical and cognitive decrements associated with dehydration have been widely researched, however the effect of dehydration on metabolism is lesser known. As climate change is causing temperatures to rise, and metabolic diseases such as type 2 diabetes are more common, the effect of dehydration on metabolism, specifically glycemic response to meals, needs to be established for future recommendations in clinical, environmental and athletic settings. Therefore, the aim of this study is to investigate the effect of acute exercise-induced dehydration on subsequent metabolic responses to feeding (i.e. glycaemia and insulinaemia).

Conditions

• Glycaemia

Interventions

Type	Name	Description
OTHER	Water intake	Water ingested to fully replace sweat losses during exercise.
OTHER	Water restriction	Water restriction to induce hypohydration of \~3% body mass through sweat losses during exercise.

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-11-01
• Completion: 2025-12-01
• First posted: 2025-02-13
• Last updated: 2025-02-13

Locations

1 site across 1 country: United Kingdom