NCT06825234

Prognostic Value of a Multidimensional Assessment for Survival in Elderly Patients With CKD 4B/5

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 390 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine a multidimensional signature (integrating frailty and patient-reported outcomes measures (PROMs) at entry into stage 4B/5 CKD) to improve prediction of renal death (dialysis, transplantation, conservative management, death).

Detailed description

In 2019, 4,263 patients starting dialysis in France were aged 75 years or older. This elderly population, often with comorbidities, poses a number of challenges for nephrologists, both in terms of initiation and modalities of dialysis and access to transplantation. Dialysis may offer little benefit in terms of survival, often at the cost of a significant impact on quality of life and number of hospitalisations. There is a current trend to offer conservative treatment as an alternative to dialysis. However, there are no objective criteria to guide this decision and the uremic syndrome may distort certain clinical perceptions. The aim of this study is to determine whether an assessment that incorporates multiple dimensions, including those of frailty, can help the clinician determine the best course of treatment for the patient.

Conditions

• Chronic Kidney Disease Stage 5
• Chronic Kidney Disease Stage 4B

Timeline

• Start date: 2025-06-01
• Primary completion: 2028-12-01
• Completion: 2028-12-01
• First posted: 2025-02-13
• Last updated: 2025-05-01

Locations

2 sites across 1 country: France