NCT06821620

Interaction of MTNR1B Genotype and Type of Breakfast (Protein-enriched v Carbohydrate-rich) on Postprandial Glucose Response.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: St. Mary's University, Twickenham · Academic / Other
• Sex: All
• Age: 18 Years – 48 Years
• Healthy volunteers: Accepted

Summary

The risk version of the MTNR1B gene (which codes for a melatonin receptor) has been associated with type II diabetes (T2D) and associated physiological markers. People with the risk version of the gene have reduced secretion of insulin when melatonin levels are high (between evening and morning) and impaired glucose tolerance when they eat late. Previous research suggests eating a protein enriched breakfast can improve glucose response. Therefore, the present study will investigate if the version of the MTNR1B gene that people have is associated with their glucose response after breakfast. Also, whether a protein enriched breakfast improves glucose response in participants with the risk version of the gene. Measures of glucose response collected over the two-week duration of the study will be compared between groups with the different versions of the gene. These findings can be used to provide personalised nutrition advice which may reduce the risk of T2D.

Conditions

• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Breakfast	Breakfast in one condition will be high carbohydrate and in the other protein enriched

Timeline

• Start date: 2024-09-09
• Primary completion: 2025-02-28
• Completion: 2025-02-28
• First posted: 2025-02-12
• Last updated: 2025-05-16

Locations

1 site across 1 country: United Kingdom