NCT06818032

Avocado and Postprandial Responses

Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Vermont Medical Center · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating. The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating: 1. Whole-wheat bread and strawberry jam 2. Whole-wheat bread, strawberry jam, and avocado 3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado) Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.

Conditions

• Healthy
• Healthy Volunteer
• Healthy Volunteers
• Healthy Adult
• Healthy Male and Female Subjects
• Healthy Subjects
• Healthy Volunteers Only
• Healthy Non-smokers

Interventions

Type	Name	Description
OTHER	Negative control	Participants will be given a breakfast meal with 76 grams of bread and 60 grams of jam per 2000 daily calories.
OTHER	Avocado	Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 84 grams of avocado per 2000 daily calories.
OTHER	Fat and fiber addition	Participants will be given a bread and jam breakfast (76 grams of bread and 60 grams of jam per 2000 daily calories) supplemented with 13 grams of fat (mix of high-oleic safflower oil, safflower oil, palm oil, and macadamia nut oil) and 5.5 grams of fiber (mix of cellulose and pectin) per 2000 daily calories.

Timeline

• Start date: 2025-03-01
• Primary completion: 2026-02-01
• Completion: 2026-06-01
• First posted: 2025-02-10
• Last updated: 2025-03-28

Locations

1 site across 1 country: United States