NCT06815315

Evaluating of the Impact of Micronutrient Interventions Among Adolescents in Mozambique

A Formative, Mixed-Methods Evaluation Assessing the Acceptability, Feasibility, and Effectiveness of Micronutrient Interventions Among Adolescents in Mozambique

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 490 (actual)
• Sponsor: World Vision US · Academic / Other
• Sex: Female
• Age: 13 Years – 20 Years
• Healthy volunteers: Accepted

Summary

This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and the impact of a nutrition curriculum on diet diversity and anemia knowledge among adolescent girls.

Detailed description

This study aimed to implement and evaluate micronutrient supplementation interventions to improve adolescent nutrition, health, and education in Mozambique. In conjunction with the Mozambique Ministries of Health, Education and Culture, we conducted a two-arm cluster-randomized trial in three secondary schools, enrolling 28 girls' clubs (14 per arm). Each club was comprised of around 18 girls aged 13 to 20 years. Using constrained sampling to balance for age and school, clubs were randomly assigned to one of two intervention groups: 1) Multiple Micronutrient Supplementation (MMS) for five months plus a Nutrition Curriculum, or 2) Iron and Folic Acid Supplementation (IFAS) plus a Nutrition Curriculum. Girls enrolled in the MMS arm consumed supplements daily for 4 months at home and weekly nutrition messages delivered through the clubs. Girls enrolled in the IFAS arm consumed supplements once a week for 4 months at school (the standard of care) and weekly nutrition messages delivered through the clubs. The study evaluated the effects of MMS and IFAS on anemia status and the impact of the nutrition curriculum on diet diversity and anemia knowledge.

Conditions

• Anemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Multiple micronutrient supplementation	The multiple micronutrient supplementation composition follows the United Nations International Multiple Micronutrient Antenatal Preparation. Each MMS tablet contains 15 micronutrients, including iron (30mg), folic acid (400 mcg), Vit A, Retinol (800 RE), vit D (200 IU), vit E (10 mg), vit C (70 mg), vit B1 (1.4 mg), vit B2 (1.4 mg), vit B6 (1.9 mg), vit B12 (2.6 mcg), niacin (18 mg), zinc (15 mg), copper (2 mg), iodine (150 mcg), selenium (65 mcg) and is consumed daily.
DIETARY_SUPPLEMENT	Iron Folic Acid Supplementation	One IFAS tablet contains Iron (60 mg) and Folic Acid (2800 μg) and is taken weekly.
BEHAVIORAL	Adolescent Nutrition Curriculum	The Adolescent Nutrition Curriculum includes five modules focused on promoting healthy behaviors to enhance nutrition, with an emphasis on consuming iron-rich foods.

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-09-30
• Completion: 2024-12-31
• First posted: 2025-02-07
• Last updated: 2025-02-07

Locations

1 site across 1 country: Mozambique