NCT06813014

Pharmacogenetics of Response to Sitagliptin (PRS)

Sitagliptin's Effects on Glucose-stimulated Insulin Secretion and Oral Glucose

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes. We are asking for healthy, non-diabetic volunteers to participate in this 7-week study. If you agree to participate, you will take part in 2 clinic visits that are 4-6 weeks apart. At the clinic visits you will have an oral glucose tolerance test (OGTT) and other blood tests to see how your body processes glucose (sugar). An OGTT is a test in which your drink glucose and then blood samples are taken afterward at specific time points to measure glucose and insulin in your blood. Each clinic visit will last about 5 hours.

Conditions

• Diabetes

Interventions

Type	Name	Description
PROCEDURE	Oral Glucose Tolerance Test	Three hour glucose tolerance test

Timeline

• Start date: 2026-12-01
• Primary completion: 2031-11-01
• Completion: 2032-12-01
• First posted: 2025-02-06
• Last updated: 2026-02-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study