NCT06809569

A Study to Evaluate Laser Speckle Contrast Imaging to Assess Changes in Chemical Agent-Induced Skin Blood Flow in Healthy Participants (MK-0000-420)

A Pilot Study to Evaluate the Use of Laser Speckle Contrast Imaging on Changes in Dermal Blood Flow Induced by Intradermal Capsaicin and Topical AITC in Healthy Participants

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Merck Sharp & Dohme LLC · Industry
• Sex: Male
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Pain is a significant issue and there is a need for better treatments for pain management. Local changes in skin blood flow can be used as an indicator of pain in the body. Capsaicin and allyl isothiocyanate (AITC) increase blood flow and cause pain. The purpose of this study is to evaluate the use of laser speckle contrast imaging (LSCI) as a tool to assess changes in skin blood flow. Researchers want to learn about the effect size and reproducibility of using LSCI to measure the blood flow response to capsaicin and AITC.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Allyl Isothiocyanate (AITC)	Topical administration
DRUG	Capsaicin	Intradermal administration
OTHER	Vehicle for AITC	Topical administration
OTHER	Vehicle for Capsaicin	Intradermal administration

Timeline

• Start date: 2023-09-25
• Primary completion: 2023-12-15
• Completion: 2023-12-15
• First posted: 2025-02-05
• Last updated: 2025-02-05

Locations

1 site across 1 country: Belgium