NCT06808841

Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study

Sufentanil is Paired Via the BMP6/SMAD Pathway Cardiac Injury in Lower Extremity Fracture Surgery Function Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Second Hospital of Shanxi Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.

Detailed description

This study explored the important role of BMP6/SMAD pathway in myocardial/injury protection by observing the effects of different doses of opioids on myocardial injury indexes hs-cTnI and BMP-6 related indexes in patients undergoing lower extremity fracture surgery, as well as the changes of BMP6 expression in bone marrow tissue of fracture end. The relationship between different doses of opioids and BMP6 and cardiac adverse events provides a theoretical basis for clinical rational drug use.

Conditions

• Myocardial Injury

Interventions

Type	Name	Description
DRUG	Sufentanil injection	Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
DRUG	Placebo	Placebo

Timeline

• Start date: 2025-02-05
• Primary completion: 2025-05-10
• Completion: 2025-05-10
• First posted: 2025-02-05
• Last updated: 2025-02-05

Locations

1 site across 1 country: China