NCT06807138

AVF Volume Blood Flow Reduction in HD Patients

AVF Volume Blood Flow Reduction in HD Patients with Chronic Heart Failure

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 86 (actual)
• Sponsor: Moscow Regional Research and Clinical Institute (MONIKI) · Other Government
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Heart failure with preserved / high cardiac output is a well-known syndrome in patients with high-flow arteriovenous fistula (AVF). However, the threshold for classifying an AVF as high-flow is currently undefined. Cardio-fistular recirculation (CFR) is often used as a criterion, with values greater than 25-30% considered cardiotoxic and associated with adverse outcomes. Additionally, CFR is one of the few easily modifiable risk factors through surgical reduction of AVF volume blood flow (Qa). The study aimed to evaluate the extent of involution of heart structural and functional changes following Qa reduction in patients with heart failure and CFR \> 25%.

Conditions

• Chronic Kidney Disease Stage 5
• Heart Failure

Timeline

• Start date: 2018-12-20
• Primary completion: 2022-04-05
• Completion: 2022-04-05
• First posted: 2025-02-04
• Last updated: 2025-02-04

Locations

1 site across 1 country: Russia