NCT06802926

Pilot Trial of Colchicine for Graft Failure in CABG

A Single Center Pilot Trial of Preliminary Effect of Colchicine on Graft Failure in Patients Underwent CABG

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Ruijin Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this pilot trial is to to evaluate the preliminary effect of oral colchicine therapy on graft outcomes in patients underwent primary isolated CABG. The main questions it aims to answer is: 1. Whether the oral colchicine therapy may reduce the failure outcome of grafts after CABG. 2. Whether it is feasible to construct a muticenter powered trial to test the superiority hypothesis. Researchers will compare colchicine to none to see if colchicine works. Participants will 1. Take oral colchicine (0.5mg daily) therapy for 12 months after CABG. 2. Clinical follow-up at Month 1, 6, and 12 after CABG. 3. Protocol-driven CCTA at Week 1 and Month 12 after CABG.

Conditions

• CABG
• Graft Failure
• Colchicine

Interventions

Type	Name	Description
DRUG	Colchicine	Oral Colchicine 0.5mg qd for 1 year

Timeline

• Start date: 2025-12-29
• Primary completion: 2027-12-01
• Completion: 2028-12-01
• First posted: 2025-01-31
• Last updated: 2026-01-02

Locations

1 site across 1 country: China