NCT06799260

Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation

Priming Effects of Ketone Monoester Supplementation on Theta-Burst Stimulation-Induced Plasticity in the Primary Motor Cortex

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Universiti Putra Malaysia · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent- and continuous-theta burst stimulation (iTBS/cTBS) are increasingly used protocols to enhance or suppress M1 excitability, respectively, beyond stimulation. However, the poor reproducibility and high inter-individual variability in responses to TBS protocols are matters of concern. This study will explore whether ketone monoester supplementation can boost TBS efficacy via their mechanistic convergence on Brain-Derived Neurotrophic Factor (BDNF).

Conditions

• Healthy Young Adult
• Neurophysiology

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone Monoester (KME)	500 mg/kg body weight of the KME supplement
DIETARY_SUPPLEMENT	Placebo	Taste-matched placebo drink
DEVICE	iTBS	iTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).
DEVICE	cTBS	cTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).

Timeline

• Start date: 2024-12-18
• Primary completion: 2025-07-01
• Completion: 2025-12-01
• First posted: 2025-01-29
• Last updated: 2025-06-25

Locations

1 site across 1 country: Malaysia