NCT06797791

Assessment of Multifocal Continuous Theta Burst Transcranial Magnetic Stimulation (cTBS) Effects in Generalized Epilepsy Patients.

Multifocal Theta Burst Transcranial Magnetic Stimulation in Generalized Epilepsy Management.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Universitatea de Stat de Medicina si Farmacie Nicolae Testemiţanu · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical study is to assess the efficacy of multifocal theta burst transcranial magnetic stimulation in the prevention of epileptic seizures in adult patients with generalized epilepsy. The main questions it aims to answer are: * How does multifocal continuous theta burst stimulation (cTBS) impact the frequency and severity of epileptic seizures? * Does cTBS influence the quality of life in patients with generalized epilepsy? * What is the safety and tolerability profile of the experimental multifocal cTBS protocol?

Conditions

• Generalized Epilepsy

Interventions

Type	Name	Description
DEVICE	Multifocal Continuous Theta Burst Transcranial Magnetic Stimulation	The experimental stimulation protocol included 3 trains of cTBS with an inter-train interval of 10 min. Each train of cTBS consisted of 600 pulses applied in blocks at the theta frequency (200ms) with a duration of 40 s. A block of pulses consisted of 3 pulses at 50Hz frequency, stimulus intensity being estimated as 80% of the RMT. Stimulation application was performed by positioning the Magventure MMC-140 coil over the vertex (Cz) according to the 10-20 EEG system overlapping bilateral motor and somatosensory cortical areas.

Timeline

• Start date: 2021-12-01
• Primary completion: 2023-08-31
• Completion: 2023-09-30
• First posted: 2025-01-28
• Last updated: 2025-01-28

Locations

2 sites across 1 country: Moldova