NCT06796140

Photoprotection Efficacy of a Sunscreen Under Visible Light Exposure by Using Two Different Simulators

Assessment of the Protective Effect of a Sunscreen on Visible Light Induced Pigmentation Using Two Different Simulators, Compared with an Untreated Control Zone

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Cosmetique Active International · Industry
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

To assess the ability of a protected agent to prevent the pigmentation under visible light exposures (VL) using two different simulators in healthy volunteers

Detailed description

The sunscreens usually used as photoprotectors are known to protect in the UV domain (UVB and UVA). However, until recently visible light (400-700 nm) was considered as devoid of any photobiological effects on cutaneous tissue. Over the last two decades, with the development of photodynamic therapies and various dermatological treatments using visible laser light, several studies have reconsidered the cutaneous effect of visible light on the skin, in particular the induction of pigmentation. This study intends to validate two simulators on visible light exposures with a referent solar formula on visible light protection.

Conditions

• Visible Light Exposures on Healthy Back Skin

Interventions

Type	Name	Description
OTHER	Visible Light Exposure - Treated zone - Left hemi-back	The treated zone located on the left side of the hemi-back was exposed to Visible Light with the simulator 1 to induce skin pigmentation (144J/cm2), 15 to 30 minutes after application.
OTHER	Visible Light Exposure - Treated zone - Right hemi-back	The treated zone located on the right side of the hemi-back was exposed to Visible Light with the simulator 2 to induce skin pigmentation (144J/cm2), 15 to 30 minutes after application.
OTHER	Visible Light Exposure - Untreated zone - Left hemi-back	The untreated zone located on the left side of the hemi-back was exposed to Visible Light with the simulator 1 to induce skin pigmentation (144J/cm2), as the same time as the treated zone.
OTHER	Visible Light Exposure - Untreated zone - Right hemi-back	The untreated zone located on the right side of the hemi-back was exposed to Visible Light with the simulator 2 to induce skin pigmentation (144J/cm2), as the same time as the treated zone.

Timeline

• Start date: 2021-03-08
• Primary completion: 2021-04-09
• Completion: 2021-04-09
• First posted: 2025-01-28
• Last updated: 2025-01-30

Locations

1 site across 1 country: Romania