NCT06795984

Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Calla IVF Center · Academic / Other
• Sex: Female
• Age: 21 Years – 40 Years
• Healthy volunteers: —

Summary

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Conditions

• Pregnancy Rate IVF
• Blastocyst IVF

Interventions

Type	Name	Description
OTHER	Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes	The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.

Timeline

• Start date: 2023-08-12
• Primary completion: 2024-08-15
• Completion: 2024-12-11
• First posted: 2025-01-28
• Last updated: 2025-01-28

Locations

1 site across 1 country: Romania