NCT06795529

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

Randomized Trial of a Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not always happen as early or as often as patients and families would like. This multi-site study will test the effectiveness of a five-session palliative care program, designed specifically for people with metastatic breast cancer and their caregivers, to strengthen communication with clinicians about what matters most in their care. The study aims to inform how palliative care services can be delivered in a more timely, personalized, and scalable way for people living with advanced cancers who have long disease trajectories, such as metastatic breast cancer.

Detailed description

The diagnosis of metastatic breast cancer can bring many challenges including physical symptoms, treatment side effects, and emotional stress for patients and their families. Palliative care specialists work alongside the oncology team to help patients and families manage symptoms, communicate effectively with their clinicians, and cope with the impact of living with cancer. Research has shown that when palliative care and oncology teams collaborate closely, patients often experience better symptom relief, clearer communication about their goals and preferences, improved quality of life and mood, and a stronger understanding of their illness. Caregivers also report feeling more supported and less distressed. The purpose of this research study is to learn whether a personalized palliative care program for people with metastatic breast cancer and their caregivers, called TARGET-PC, can further improve communication, symptom management, coping skills, and understanding of care. In this study, 400 patients with metastatic breast cancer and their caregivers will be randomly assigned to receive either the TARGET-PC program or enhanced usual care. Enhanced usual care includes an electronic prompt that reminds oncology clinicians to discuss and record each patient's goals and preferences for care. The study will take place at the Massachusetts General Hospital Cancer Center, Penn Abramson Cancer Center, and Duke Cancer Center.

Conditions

• Metastatic Breast Cancer

Interventions

Type	Name	Description
OTHER	Palliative Care Intervention, "TARGET-PC"	Palliative care intervention focused on eliciting patients' goals and values to facilitate discussion and documentation of health care preferences.
OTHER	Enhanced Usual Care	Oncology clinicians will receive an electronic message to encourage them to discuss and document their patients' health care preferences.

Timeline

• Start date: 2025-10-01
• Primary completion: 2029-10-01
• Completion: 2030-03-31
• First posted: 2025-01-28
• Last updated: 2025-11-18

Locations

3 sites across 1 country: United States