NCT06794515

cGMP: Metabolism and Appetite Modulation

Metabolic Effects of cGMP: From Amino Acid Absorption Kinetics to Appetite Modulation

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Universidade Nova de Lisboa · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of patients with phenylketonuria. Therefore, the aim of this project is to study the impact of acute ingestion of casein glycomacropeptide supplemented with amino acids (cCGMP-AAs) alone or in combination with two different meals on amino acid absorption kinetics, glycaemic and insulinemic response, and on acute markers of appetite control. The main findings of this project will bring new insights into the dietary management of these patients, which may lead to improvements in protein substitutes formulations.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	cGMP-AAs alone (20 g of protein equivalent)	cGMP-AAs alone (20 g of protein equivalent)
DIETARY_SUPPLEMENT	cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple	cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple
DIETARY_SUPPLEMENT	cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil	cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil

Timeline

• Start date: 2025-02-03
• Primary completion: 2025-03-28
• Completion: 2025-04-24
• First posted: 2025-01-27
• Last updated: 2025-01-27

Locations

1 site across 1 country: Portugal