NCT06794125

An Evaluation of Dose-escalation for Intrathoracic Tumours

A Phase II/III Randomized Evaluation of Dose-escalation With Esophageal-sparing for Palliation of Intrathoracic Tumours (PREVENT)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 141 (estimated)
• Sponsor: Chris Goodman · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT). The investigators hypothesize that the use of advanced radiation planning techniques to optimize dose to esophagus will permit the safe delivery of a modestly dose-escalated five-fraction course of palliative radiation to intrathoracic malignancies. This approach aims to deliver higher biologically effective doses while improving toxicity when compared to conventional approaches with the goal of prolonging high-quality overall survival.

Conditions

• Lung Cancers

Interventions

Type	Name	Description
RADIATION	Hypofractionated Radiation Therapy	Hypofractionated, dose-escalated, esophageal-sparing intensity modulated radiation therapy
RADIATION	Radiation Therapy	standard of care palliative thoracic radiotherapy using volumetric modulated arc therapy/intensity-modulating radiotherapy

Timeline

• Start date: 2025-09-03
• Primary completion: 2029-03-01
• Completion: 2029-03-01
• First posted: 2025-01-27
• Last updated: 2026-02-04

Locations

3 sites across 1 country: Canada