NCT06794060

Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging

Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging：a Multicenter, Double-blind, Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 354 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C. The main questions it aims to answer are: * Does Vitamin C supplementation improve the ovarian reserve prediction score? * What medical problems do participants have when taking Vitamin C supplementation? Researchers will compare Vitamin C to a placebo (a look-alike substance that contains no drug) to see if drug Vitamin C works to improve ovarian reserve in women with ovarian aging. Participants will: * Take Vitamin C or a placebo every day for 12 months * Visit the clinic once every 4 weeks for follow-up and drug distribution. * Return the Vitamin C box at each visit. * Report any adverse effects of treatment to the doctor. * Fill out a questionnaire at each visit. * After 6 months and 12 months of intervention, take blood test and ultrasonic examination.

Conditions

• Premature Ovarian Insufficiency
• Ovarian Reserve Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin C (Ascorbic Acid)	Participants swallow synthetic vitamin C tablets 500mg with water, twice a day.
DIETARY_SUPPLEMENT	Vitamin C (Ascorbic Acid)	Participants swallow naturral vitamin C tablets 500mg with water, twice a day.
OTHER	Placebo	Participants swallow tablets with the same texture, flavor, and appearance as the experimental group 500mg with water, twice a day.

Timeline

• Start date: 2025-07-02
• Primary completion: 2025-12-31
• Completion: 2027-08-31
• First posted: 2025-01-27
• Last updated: 2025-06-26