NCT06792149

Prediction of Drug Response in Gastric Cancer Based on 3D Bioprinting

Research on the Value of Predicting Drug Efficacy Based on 3D Bioprinting for Constructing In Vitro Gastric Cancer Models

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The therapeutic regimens for adjuvant and neoadjuvant chemotherapy in gastric cancer (GC) predominantly hinge on clinical experience. Consequently, there is an imperative need for preclinical models to facilitate the guidance of individualized medicine. The investigators plan to establish three-dimensional (3D) bioprinted GC models derived from surgically resected tumor tissues of GC patients. These in vitro 3D models will be subjected to treatment with the identical chemotherapy drugs administered to the corresponding patients from whom the models are sourced. The sensitivity of the chemotherapy drugs will be assayed within the in vitro models, and the actual response to chemotherapy in patients will be meticulously evaluated. This observational study aims to substantiate the potential utility of 3D bioprinted tumor models in prognosticating the response to chemotherapy in GC.

Conditions

• STOMACH NEOPLASM

Interventions

Type	Name	Description
PROCEDURE	surgical resection	Surgical resection will be performed for locoregional lesions .
OTHER	Adjuvant chemotherapy	Regimens of adjuvant chemotherapy are directed by clinical guidance and experience.
OTHER	neoadjuvant therapy	Regimens of neoadjuvant chemotherapy are directed by clinicalguidance and experience

Timeline

• Start date: 2023-10-01
• Primary completion: 2025-10-31
• Completion: 2025-12-31
• First posted: 2025-01-24
• Last updated: 2025-01-24

Locations

1 site across 1 country: China