NCT06791226

Evaluating the Usefulness of 18F-AlF-FAPI PET/ CT in Orbital Neoplasms

Evaluating the Potential Usefulness of 18F-AlF-FAPI PET/ CT in Patients With Orbital Neoplasms and Compared With 18F-FDG PET/ CT

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 3 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the potential usefulness of 18F-AlF-FAPI positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in orbital neoplasms, and compared with 18F-FDG PET/CT.

Detailed description

Subjects with orbital neoplasms underwent contemporaneous 18F-AlF-FAPI and 18F-FDG PET/CT for initial assessment. Tumor uptake was quantified by the maximum standard uptake value (SUVmax). The numbers of metastatic lesions of 18F-FDG and 18F-AlF-FAPI PET/CT were recorded by visual interpretation. The sensitivity, specificity, and accuracy of 18F-AlF-FAPI, 18F-FDG PET/CT were calculated and compared to evaluate the diagnostic accuracy.

Conditions

• Orbital Neoplasms

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-AlF-FAPI PET/CT, 18F-FDG PET/CT	Subjects with orbital neoplasms underwent contemporaneous 18F-AlF-FAPI and 18F-FDG PET/CT for diagnosis and staging.

Timeline

• Start date: 2024-07-16
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2025-01-24
• Last updated: 2025-01-24

Locations

1 site across 1 country: China