NCT06791148

Low-dose Radiotherapy Combined With Chemotherapy and AK112 as Second-line Treatment in Patients With Advanced G/GEJ Cancer

Low-dose Radiotherapy Combined With Albumin-bound Paclitaxel and AK112 as Second-line Treatment in Patients With Advanced Gastric or Gastroesophageal Junction（G.GEJ）Cancer Who Failed First-line Therapy：a Single，Phase II Trial

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate the efficacy and safety of the combination of albumin-bound paclitaxel and AK112 with low-dose radiotherapy in patients with gastric adenocarcinoma and gastroesophageal junction adenocarcinoma who have failed first-line standard therapy.

Conditions

• Gastric Cancer

Interventions

Type	Name	Description
RADIATION	Low-dose radiotherapy	2Gy/f，q3w，×4f
DRUG	albumin-bound paclitaxel	100-120mg/m2,i.v.,d2,d9,q3w
DRUG	AK112	20mg/kg, i.v., d2, q3w

Timeline

• Start date: 2024-07-10
• Primary completion: 2027-07-10
• Completion: 2027-12-10
• First posted: 2025-01-24
• Last updated: 2025-01-24

Locations

1 site across 1 country: China