NCT06789263

Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects

Clinical Study to Evaluate the Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects: Randomized, Double-blind, Placebo-controlled, Cross-over Design

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Rousselot BVBA · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Aim of the study is to investigate the postprandial response on blood glucose, insulin, C-peptide, incretin response and gastric emptying after intake of collagen hydrolysate compared to placebo in normoglycemic and in prediabetic participants. This will be investigated in a cross-over randomized double-blind placebo controlled study design. In an exploratory part II, timing of intake of collagen hydrolysate in relation to the mixed meal will be investigated in a subgroup of 50% of the participants.

Conditions

• Prediabetes
• Normoglycemic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Collagen hydrolyzed peptides	Dissolved in flavoured water, single dose, 10 g
OTHER	Placebo	Single dose

Timeline

• Start date: 2025-01-29
• Primary completion: 2025-09-08
• Completion: 2025-09-08
• First posted: 2025-01-23
• Last updated: 2025-12-09

Locations

1 site across 1 country: Germany