NCT06788743

Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to explore whether the use of propofol for anesthesia maintenance in elderly diabetic patients undergoing elective non-cardiac major surgery can reduce the incidence of postoperative delirium. This study will provide new perspectives for improving perioperative management in elderly diabetic patients and optimizing anesthesia management strategies to reduce the risk of postoperative delirium.

Conditions

• Postoperative Delirium (POD)
• Diabetes

Interventions

Type	Name	Description
DRUG	TIVA ( anesthesia with propofol and remifentanil)	Participants assigned to the TIVA group will receive propofol combined with remifentanil for anesthesia maintenance during the surgery
DRUG	VA（anesthesia with sevoflurane and remifentanil）	Participants assigned to the VA group will receive sevoflurane combined with remifentanil for anesthesia maintenance during the surgery.

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-04-24
• Completion: 2026-05-31
• First posted: 2025-01-23
• Last updated: 2026-04-16

Locations

1 site across 1 country: China