NCT06786780

Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids

A Single-Arm, Single-Center, Phase II Study to Evaluate the Predictive Value of Organoids for Radiotherapy and Chemotherapy Efficacy in Cervical Cancer

• Status: Enrolling By Invitation
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Chongqing University Cancer Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a single-arm, single-center, open-label, Phase II study aimed at assessing the efficacy of organoids in predicting the response to radiotherapy and chemotherapy in cervical cancer

Detailed description

By constructing cervical cancer organoids, establishing a radiochemotherapy prediction model based on organoids, and exploring radiotherapy resistance-related molecules as new therapeutic targets for locally advanced cervical cancer, the feasibility and effectiveness are assessed. Utilizing the constructed model for molecular mechanism discussions and effective drug screening, new avenues for the treatment of cervical cancer patients with radiochemotherapy resistance are sought.

Conditions

• Cervical Cancer Treated with Pelvic Radiotherapy
• Cervical Cancers

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Drug: Cisplatin	Organoids were constructed prior to simultaneous radiochemical therapy

Timeline

• Start date: 2023-01-01
• Primary completion: 2025-06-01
• Completion: 2026-06-01
• First posted: 2025-01-22
• Last updated: 2025-03-26

Locations

1 site across 1 country: China