NCT06785922

Differences in Gastric Microbiota in Patients Who Were Infected Between CagA Positive and Negative Helicobacter Pylori

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to study the differences in gastric microbiota (Diversity index) between patients who were infected with CagA-positive Helicobacter pylori and CagA-negative Helicobacter pylori. The main question it aims to answer are: The effect of Helicobacter pylori typing (CagA status) on gastric microbiota, what is the different? Patients indicated for EGD at Siriraj Endoscopic Center will undergo a Helicobacter pylori test (Rapid urease test) If the result is positive, a stomach biopsy for gastric microbiota testing and CagA antibody testing will be conducted. Then, the patients will be divided into two groups: CagA-positive Helicobacter pylori and CagA-negative Helicobacter pylori. To compare the differences in gastric microbiota in terms of species and biodiversity, as well as endoscopic results, etc.

Conditions

• Gastric Microbiota
• Helicobacter Pylori
• CagA
• Gastric Cancer

Interventions

Type	Name	Description
PROCEDURE	Stomach biopsy for gastric microbiota	Stomach biopsy for gastric microbiota testing (16S RNA sequencing)

Timeline

• Start date: 2025-01-12
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-01-21
• Last updated: 2025-01-21

Locations

1 site across 1 country: Thailand