NCT06782451

Development of Preclinical Models Derived From Tumors With a Molecular Abnormality of Interest to Test Their Sensitivity to New Anti-tumor Therapies.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Centre Antoine Lacassagne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to collect tumor samples from patients carrying a mutation of interest to develop a cell culture technique for "spheroids. The goal is to use these spheroids to model responses to anticancer treatments. Various therapeutic molecules can be tested on these spheroids, enabling the evaluation of the potential of new molecules or the activity of existing ones specifically on the tumor (bearing the mutation of interest) from which the spheroid was developed. Tumor samples will be collected as part of biopsies or surgeries conducted during routine patient care.

Conditions

• Neoplasm Malignant

Interventions

Type	Name	Description
PROCEDURE	Surgery or biopsy	A part of the tumor sample collected during the surgery or the biopsy performed as part of routine patient care will be used for the research.
PROCEDURE	Blood sample	38 mL of blood will be taken for the study.

Timeline

• Start date: 2025-05-02
• Primary completion: 2030-07-02
• Completion: 2030-07-02
• First posted: 2025-01-17
• Last updated: 2025-09-29

Locations

1 site across 1 country: France