Trials / Recruiting
RecruitingNCT06778083
STI Prophylaxis and Emergence of Antimicrobial Resistance
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 108 (estimated)
- Sponsor
- University College, London · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis. The study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.
Conditions
- Sexually Transmitted Infection (STI) Prevention
- Antibiotic Prophylaxis
- Antibiotic Resistance, Bacterial
- Microbiome
- Doxycycline
Timeline
- Start date
- 2025-02-10
- Primary completion
- 2027-04-30
- Completion
- 2027-04-30
- First posted
- 2025-01-16
- Last updated
- 2025-03-27
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT06778083. Inclusion in this directory is not an endorsement.