NCT06776042

Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.

Conditions

• Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Interventions

Type	Name	Description
OTHER	Nasal brushing of the olfactory cleft	Nasal brushing of the olfactory cleft
OTHER	Smell testing	Smell testing using the Sniffin' Sticks Test

Timeline

• Start date: 2023-05-22
• Primary completion: 2025-12-01
• Completion: 2026-09-30
• First posted: 2025-01-15
• Last updated: 2025-01-15

Locations

1 site across 1 country: Belgium