NCT06775769

Endometrioma Sclerotherapy and Ovarian Preservation

Endometrioma Sclerotherapy and Ovarian Preservation: a Randomised Control Trial of Laparoscopic Sclerotherapy vs Traditional Excision of Endometrioma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Chelsea and Westminster NHS Foundation Trust · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

A randomised controlled trial assessing ovarian reserve after laparoscopic ethanol sclerotherapy of ovarian endometrioma compared to standard treatment of surgical excision of endometrioma. Secondary outcomes will include endometrioma recurrence, symptomatology and inflammatory environment.

Detailed description

Participants with endometrioma(ta), identified on imaging, who are opting for surgical management of endometriosis will be randomly allocated to laparoscopic ethanol sclerotherapy of endometrioma or laparoscopic surgical excision of endometrioma(ta). Any concurrent endometriosis identified at surgery will be excised as per routine care. Ovarian reserve will be assessed by serum anti-Mullarian hormone (AMH) and antral follicle count (AFC), recurrence will me assessed by transvaginal ultrasound, symptomatology will be assessed by EHP-30 questionnaires and changes in inflammation assessed in serum and endometrial biopsy. Each participant will be followed up for a total of 24 months from surgery.

Conditions

• Endometrioma

Interventions

Type	Name	Description
PROCEDURE	Sclerotherapy	Laparoscopic ethanol sclerotherapy of endometrioma
PROCEDURE	Routine Care	Routine surgical management of endometrioma

Timeline

• Start date: 2025-02-21
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2025-01-15
• Last updated: 2025-11-25

Locations

1 site across 1 country: United Kingdom