NCT06774885

ROLE OF FOLIC ACID IN THE MANAGEMENT OF ADJUVANT ENDOCRINE THERAPY-INDUCED HOT FLASHES IN BREAST CANCER PATIENTS

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Future University in Egypt · Academic / Other
• Sex: Female
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The study's objective is to investigate the role of folic acid administration in the management of hot flashes associated with adjuvant endocrine therapy in patients with breast cancer.

Detailed description

Folic acid is one of the B vitamins that when absorbed into its active form is converted to tetrahydrofolate. Folate is an essential cofactor for the biosynthesis of norepinephrine and serotonin. Studies have also noted that folate, with a mechanism like hormone replacement therapy (HRT), can improve hot flashes by interfering with monoamine neurotransmitters called norepinephrine and serotonin .The purpose of the current study is to investigate the role of folic acid administration in the management of hot flashes associated with adjuvant endocrine therapy in patients with breast cancer.

Conditions

• THERAPY-INDUCED HOT FLASHES IN BREAST CANCER PATIENTS

Interventions

Type	Name	Description
DRUG	Folic Acid 1 Mg Oral Tablet	1 mg oral folic acid tablet
DRUG	Folic Acid 5 Mg Oral Tablet	5 mg oral folic acid tablet

Timeline

• Start date: 2025-02-09
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2025-01-14
• Last updated: 2025-01-14