Trials / Not Yet Recruiting

Not Yet RecruitingNCT06774768

Use of Machine-learning Algorithms, Biomarkers and Measures of Quality of Life to Personalize Medical Management of Liver and Heart Transplant Recipients

Status: Not Yet Recruiting
Phase: —
Study type: Observational
Enrollment: 1,000 (estimated)

Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Not accepted

Summary

This is an observational, low risk tissue based, non-pharmacological, retrospective-prospective study for adults heart and liver transplant patients, related to IRCCS Azienda Ospedaliero-Universitaria di Bologna (IRCCS AOUBO). This clinical study is part of the national multicentric project DARE. The project has the wide overarching aim to develop digital solutions for personalized healthcare.

Detailed description

This study is structured in two phases: 1) a retrospective phase that aims to develop ML-based scores that can allow to predict at patient level the risk of infections, cardiovascular diseases, new onset malignancies and chronic graft dysfunction, and describing the trajectory of this risk over time; 2) a prospective phase in which we test the association of biomarkers, QoL and frailty assessments with the ML-scores applied prospectively in heart and liver transplant recipients.

Conditions

Timeline

Start date: 2025-01-30
Primary completion: 2029-12-31
Completion: 2029-12-31
First posted: 2025-01-14
Last updated: 2025-01-14

Locations

2 sites across 1 country: Italy

Source: ClinicalTrials.gov record NCT06774768. Inclusion in this directory is not an endorsement.