NCT06774053

Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - the SPECTRA Study

Swiss Prospective Cohort of TRAnsgender and Gender Diverse Individuals - the SPECTRA Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 600 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to understand the factors influencing the well-being and health of transgender and gender-diverse (TGD) individuals undergoing gender-affirming therapies in Switzerland. The study population includes TGD individuals aged 16 and older, at various stages of their medical transition, including those who have discontinued or detransitioned. The main question is: What are the key factors influencing the well-being and health outcomes of transgender and gender-diverse individuals undergoing gender-affirming therapies? Researchers will compare health outcomes across different subgroups, such as those at different stages of transition or detransition, to examine the effects of gender-affirming therapies. Participants will: Complete electronic questionnaires assessing gender congruence, quality of life, mental health, and other outcomes. Provide biological samples (e.g., blood, urine, stool, and skin swabs) for laboratory analysis. Undergo clinical evaluations related to endocrinology, fertility, dermatology, and urology as part of their routine follow-up.

Conditions

• Transgender Individuals
• Gender Incongruence

Timeline

• Start date: 2025-01-30
• Primary completion: 2045-01-01
• Completion: 2045-01-01
• First posted: 2025-01-14
• Last updated: 2025-01-14

Locations

2 sites across 1 country: Switzerland