NCT06773351

A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane

A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane During Anesthesia Induction

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Feng Gao · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Intravenous and inhalation combined anesthesia is a commonly used method for maintaining general anesthesia in clinical practice. This study aims to explore the interaction between ciprofol and sevoflurane. By employing response surface methodology, we constructed a three-dimensional pharmacodynamic interaction surface for various dose combinations of ciprofol and sevoflurane. This approach allows us to determine the nature of the interaction between the two drugs at any given level, thereby providing a ciprofol understanding of the dose-response relationship when ciprofol and sevoflurane are used in combination. This knowledge will serve as a theoretical basis for rational drug administration during surgery.

Conditions

• Induction of General Anesthesia

Interventions

Type	Name	Description
DRUG	Sevoflurane 0 + different doses of ciprofol	Sevoflurane 0% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.6mg/kg, respectively.
DRUG	Sevoflurane 0.7% + different doses of ciprofol	Sevoflurane 0.7% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.5mg/kg, respectively.
DRUG	Sevoflurane 1.0% + different doses of ciprofol 0.05	Sevoflurane 1.0% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.
DRUG	Sevoflurane 1.5% + differnet doses of ciprofol	Sevoflurane 1.5% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.
DRUG	Sevoflurane 2.0% + different doses of ciprofol	Sevoflurane 2.0% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.
DRUG	Sevoflurane 2.5% + different doses of ciprofol	Sevoflurane 2.5% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.
DRUG	Ciprofol 0 + different end-expiratory concentration of sevoflurane	Ciprofol 0 combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5%, respectively.
DRUG	Ciprofol 0.05mg/kg + different end-expiratory concentration of sevoflurane	Ciprofol 0.05 mg/kg combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5 %, respectively.
DRUG	Ciprofol 0.1mg/kg + different end-expiratory concentration of sevoflurane	Ciprofol 0.1mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.
DRUG	Ciprofol 0.2 mg/kg + different end-expiratory concentration of sevoflurane	Ciprofol 0.2 mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.
DRUG	Ciprofol 0.3 mg/kg + different end-expiratory concentration of sevoflurane	Ciprofol 0.3 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.
DRUG	Ciprofol 0.4 mg/kg + different end-expiratory concentration of sevoflurane	Ciprofol 0.4 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2025-01-14
• Last updated: 2025-01-14