NCT06772727

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Comparison of Hemodynamic Effect of Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy: a Randomized Controlled Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 149 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Lidocaine-based anesthesia had been recently reported as a successful regimen for induction of anesthesia in elderly population with better hemodynamic profile than opioid-based induction. The investigators hypothesize that lidocaine-based induction of anesthesia would provide superior hemodynamic profile compared to conventional opioid-based induction of anesthesia in emergency laparotomy.

Conditions

• Post-induction Hypotension
• Lidocaine
• Opioid
• Emergency Laparotomy

Interventions

Type	Name	Description
DRUG	Lidocaine	After preoxygenation with 100% oxygen for 3 minutes, the study drug (lidocaine) will be administered. Patients will receive 1 mg/kg lidocaine of 10 mg/mL lidocaine solution (prepared by diluting 5 mL of lidocaine 20% in saline to a total volume of 10 mL)
DRUG	Fentanyl	After preoxygenation with 100% oxygen for 3 minutes, the study drug (fentanyl) will be administered. Patients will receive 1 mcg/kg fentanyl of 10 mcg/mL fentanyl solution (prepared by diluting 100 mcg fentanyl in saline to a total volume of 10 mL).
DRUG	Propofol	After administration of the study drug, all patients will receive 2 mg/kg propofol intravenously
DRUG	Succinyl choline	After loss of consciousness, 1 mg/kg succinyl choline will be administered over 5 seconds, and tracheal intubation will be done through direct laryngoscopy after 60 seconds.

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-10-30
• Completion: 2025-10-30
• First posted: 2025-01-13
• Last updated: 2026-03-05

Locations

1 site across 1 country: Egypt