NCT06772675

Vancomycin Reduction Practices (VRP) in the NICU

Implementing Vancomycin Reducing Practices (VRP) in Preterm Infants

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (estimated)
• Sponsor: Children's Hospital of Philadelphia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Conditions

• Antibiotic Stewardship
• Neonatal Sepsis, Late-Onset
• Vancomycin

Interventions

Type	Name	Description
BEHAVIORAL	External Facilitation	Designated external facilitators will conduct monthly meetings with local champions at each site. Designated facilitators will follow the developed facilitation guide, that includes content area to cover in each meeting, case scenarios as examples, and tips on how to communicate and support the internal facilitators. The goal is to enable problem-solving and support the local champion in implementing VRP with fidelity

Timeline

• Start date: 2025-06-02
• Primary completion: 2027-09-01
• Completion: 2027-09-01
• First posted: 2025-01-13
• Last updated: 2025-12-24

Locations

13 sites across 1 country: United States