NCT06770647

Predicting Outcomes of Breast-Conserving Surgery in Breast Cancer Patients Using the Modified 5-Item Frailty Index

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 96,586 (actual)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment. The modified 5-item frailty index (mFI-5), a well-validated tool for assessing frailty, has shown predictive utility in other surgical contexts but remains under-explored in BCS. Methods: Using the American College of Surgeons National Surgical Quality Improvement Program database (2008-2021), the investigators identified adult female breast cancer patients who underwent BCS. Frailty was assessed using the mFI-5, scored from 0 to 5, with higher scores indicating greater frailty. Multivariable logistic regression was employed to evaluate associations between mFI-5 scores and postoperative outcomes. Main question: Can the mFI-5 predict adverse postoperative outcomes in breast-conserving surgery patients?

Conditions

• Retrospective Study

Timeline

• Start date: 2024-07-01
• Primary completion: 2024-08-01
• Completion: 2024-12-15
• First posted: 2025-01-13
• Last updated: 2025-01-13

Locations

1 site across 1 country: Germany