NCT06765642

The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.

Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.

Detailed description

The goal of this study is to determine the efficacy of a high-dose of a excitatory-specific patterned Transcranial Magnetic Stimulation (i.e., intermittent theta-burst stimulation - iTBS) protocol as a neuromodulatory tool on the neuromotor recovery (corticospinal excitability and motor performance) in individuals with chronic stroke using either the conventional iTBS protocol (600 pulses; iTBS600) or a high dose iTBS protocols (a total of 2400 pulses) over a single spot (Focal iTBS; FiTBS2400) and 4 spots (Diffuse iTBS: DiTBS2400) on the ipsilesional hemisphere. The use of this approach aims to potentially maximize motor recovery in chronic stroke by harnessing corticospinal plasticity and modulating motor learning behavior.

Conditions

• Stroke
• Stroke Patients
• Arm Weakness as a Consequence of Stroke
• Brain Stimulation
• Transcranial Magnetic Stimulation Repetitive
• Transcranial Magnetic Stimulation
• Motor Learning
• Chronic Stroke Patients
• Chronic Stroke Survivors

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transcranial Magnetic Stimulation	The use of this approach aims to potentially maximize motor recovery in chronic stroke by harnessing corticospinal plasticity and modulating motor learning behavior.

Timeline

• Start date: 2025-06-09
• Primary completion: 2027-04-13
• Completion: 2027-04-30
• First posted: 2025-01-09
• Last updated: 2025-07-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study