NCT06762379

Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC Through Liquid Biopsy Integration

Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 125 (estimated)
• Sponsor: European Institute of Oncology · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Implementation of a new algorithm for HRR gene mutation testing in patients with mPC through liquid biopsy integration

Detailed description

Analysis of the current clinical landscape of mPC Italy to identify gaps and opportunities for improvement. Patient identification and enrollment Blood sample collection and plasma purification ctDNA extraction and NGS analysis of homologous recombination repair (HRR) genes. Clinical Real-World Data (RWD) and molecular analysis data collection Testing algorithm development based on collected data Finalization and sharing of a best practice model for diagnostic procedures in mPC patients

Conditions

• Metastatic Prostate Cancer (mPC)

Timeline

• Start date: 2024-12-20
• Primary completion: 2027-12-31
• Completion: 2030-12-31
• First posted: 2025-01-07
• Last updated: 2026-03-24

Locations

1 site across 1 country: Italy