NCT06761079

Comparison of Thoracolumbar Interfascial Plane Block (TLIP-block) and Local Anesthetic (LA) Infiltration in Minimally Invasive Spine Surgery: A Randomized Controlled Trial

Comparison of Thoracolumbar Interfascial Plane Block (TLIP-block) and Local Anesthetic Infiltration in Minimally Invasive Spine Surgery: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Queen Savang Vadhana Memorial Hospital, Thailand · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare the effectiveness of the thoracolumbar interfascial plane block (TLIP block) versus local anesthetic (LA) infiltration in managing postoperative pain in minimally invasive surgery (MIS) for spine surgery. The primary outcome was total morphine consumption. Secondary outcomes included pain scores using the the numerical verbal scale (NRS), opioid-related side effects, time of the first request for rescue analgesia, time to ambulation and hospital length of stay.

Detailed description

A single-center, prospective, double-blind, randomized controlled trial at Queen Savang Vadhana Memorial Hospital. All 40 enrolled patients were randomized to receive the assigned intervention, Thoracolumbar interfascial plane group (TLIP group) and local anesthetic (LA) infiltration group (LA group). * For TLIP group, patients will receive ultrasound-guild bilateral TLIP block with a total of 40 ml of 0.25% Bupivacaine. * For LA group, patients will receive local anesthetic infiltration with a same drug by orthopedic surgeon. At the end of surgery, patients were extubated and transferred to the PACU before being shifted to the orthopedic ward. Postoperative assessments began upon admission to the PACU, designated as time zero, and continued at regular intervals in the orthopedic ward (6-, 8-, 12- and 24-hours post-surgery).

Conditions

• Percutaneous Pedicular Screw (PPS) Fixation
• Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS TLIF) Surgeries

Interventions

Type	Name	Description
PROCEDURE	Thoracolumbar interfascial plane block	Ultrasound-guild bilateral Thoracolumbar interfascial plane block with a total 40 ml, 0.25% bupivacaine by anesthesiologist
PROCEDURE	Local anesthetic infiltration	0.25%bupivacaine infiltration at surgical wound site by orthopedic surgeon

Timeline

• Start date: 2024-01-16
• Primary completion: 2024-12-16
• Completion: 2024-12-25
• First posted: 2025-01-07
• Last updated: 2025-01-07

Locations

1 site across 1 country: Thailand