NCT06760377

Dietary Supplements for Reduction of Intestinal Permeability Levels

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 85 (estimated)
• Sponsor: Universidad Complutense de Madrid · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

A randomised and controlled trial, in which the effect of a dietary supplement is evaluated for reduction of intestinal permeability levels of subjects with high levels of zonulin in feces

Detailed description

Randomized clinical trial, with masking of the statistician and the evaluator, to assess the effect of a food supplement, composed of substances that promote intestinal mucosa repair, on the levels of zonulin in feces and consequently on intestinal permeability. A control group of subjects not receiving any type of supplementation will be used to compare the effectiveness of the treatment. The main objective of this study is to determine if the use of a dietary supplement composed of glutamine, butyrate and lion's mane, among others, corrects the levels of zonulin in feces.

Conditions

• Intestinal Permeability
• Leaky Gut Syndrome
• Zonulin

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Dietary supplement Group	Subjects belonging to the experimental group will be provided with the PermeaIntest supplement, which they will take for 60 days, 1 sachet in the morning and 1 sachet in the evening in half a glass of water. Subjects will have a stool sample collected before and after ingestion of the dietary supplement.

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-04-01
• Completion: 2025-06-01
• First posted: 2025-01-06
• Last updated: 2025-01-06

Locations

1 site across 1 country: Spain