NCT06759155

Phase II Clinical Trial of De-Intensified Therapy in Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Vermont Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

HPV-associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) is a type of cancer that affects parts of the throat, like the tonsils and the base of the tongue. The treatments for OPSCC, which may include surgery, radiation, and chemotherapy, often cause serious side effects, such as loss of taste, dry mouth, and long-term problems with swallowing. These side effects can lower patients' quality of life and make it difficult for them to eat and speak normally. This study aims to explore whether using lower doses of radiation after surgery can help improve long-term swallowing function in patients with HPV-positive OPSCC. By doing this, the study team hopes to reduce treatment-related side effects while maintaining good cancer control.

Conditions

• OPSCC
• Oropharyngeal Squamous Cell Carcinoma (SCC)
• HPV Associated Cancers

Interventions

Type	Name	Description
RADIATION	de-intensified radiation	Adjuvant radiation will be administered on a de-intensified schedule.

Timeline

• Start date: 2025-01-01
• Primary completion: 2030-01-01
• Completion: 2030-01-01
• First posted: 2025-01-06
• Last updated: 2025-01-06